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pentobarbital will reduce the extent or outcome of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will minimize the level or result of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with robust CYP3A4 inducers isn't advisablepentobar